Glukoosi: BUBR1 (Pub Med haku. Sitaatti 20 artikkelia) seulottavaksi

See 151 articles about BUBR1 gene function

See also: 42 tests for BUBR1 in the Genetic Testing Registry

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Select item 316498511.

MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate.

Abdelfatah S, Berg A, Huang Q, Yang LJ, Hamdoun S, Klinger A, Greten HJ, Fleischer E, Berg T, Wong VKW, Efferth T.

Acta Pharm Sin B. 2019 Sep;9(5):1021-1034. doi: 10.1016/j.apsb.2019.02.001. Epub 2019 Feb 10.

PMID:: 31649851

Free PMC Article

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Select item 316064082.

C12, a combretastatin-A4 analog, exerts anticancer activity by targeting microtubules.

Kumari A, Srivastava S, Manne RK, Sisodiya S, Santra MK, Guchhait SK, Panda D.

Biochem Pharmacol. 2019 Oct 10;170:113663. doi: 10.1016/j.bcp.2019.113663. [Epub ahead of print]

PMID:: 31606408

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Select item 315442943.

lncRNA CCAT1 is a biomarker for the proliferation and drug resistance of esophageal cancer via the miR-143/PLK1/BUBR1 axis.

Hu M, Zhang Q, Tian XH, Wang JL, Niu YX, Li G.

Mol Carcinog. 2019 Dec;58(12):2207-2217. doi: 10.1002/mc.23109. Epub 2019 Sep 22.

PMID:: 31544294

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Select item 315239014.

Downregulation of Mad2 and BubR1 increase the malignant potential and nocodazole resistance by compromising spindle assembly checkpoint signaling pathway in cervical carcinogenesis.

Wang L, Wang J, Jin Y, Zheng J, Yang Y, Xi X.

J Obstet Gynaecol Res. 2019 Sep 15. doi: 10.1111/jog.14120. [Epub ahead of print]

PMID:: 31523901

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Select item 315113085.

Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56.

Hayward D, Bancroft J, Mangat D, Alfonso-Pérez T, Dugdale S, McCarthy J, Barr FA, Gruneberg U.

J Cell Biol. 2019 Oct 7;218(10):3188-3199. doi: 10.1083/jcb.201905026. Epub 2019 Sep 11.

PMID:: 31511308

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Select item 314802996.

Melatonin Improves In Vitro Development of Vitrified-Warmed Mouse Germinal Vesicle Oocytes Potentially via Modulation of Spindle Assembly Checkpoint-Related Genes.

Wu Z, Pan B, Qazi IH, Yang H, Guo S, Yang J, Zhang Y, Zeng C, Zhang M, Han H, Meng Q, Zhou G.

Cells. 2019 Aug 30;8(9). pii: E1009. doi: 10.3390/cells8091009.

PMID:: 31480299

Free PMC Article

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Select item 314784497.

Loss of CENPF leads to developmental failure in mouse embryos.

Zhou CJ, Wang XY, Han Z, Wang DH, Ma YZ, Liang CG.

Cell Cycle. 2019 Oct;18(20):2784-2799. doi: 10.1080/15384101.2019.1661173. Epub 2019 Sep 3.

PMID:: 31478449

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Select item 312800488.

Airborne particulate matter induces mitotic slippage and chromosomal missegregation through disruption of the spindle assembly checkpoint (SAC).

Santibáñez-Andrade M, Sánchez-Pérez Y, Chirino YI, Morales-Bárcenas R, Herrera LA, García-Cuellar CM.

Chemosphere. 2019 Nov;235:794-804. doi: 10.1016/j.chemosphere.2019.06.232. Epub 2019 Jul 1.

PMID:: 31280048

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Select item 312572859.

BubR1 Is Essential for Thio-Dimethylarsinic Acid-Induced Spindle Assembly Checkpoint and Mitotic Cell Death for Preventing the Accumulation of Abnormal Cells.

Kita K, Imai Y, Asaka N, Suzuki T, Ochi T.

Biol Pharm Bull. 2019;42(7):1089-1097. doi: 10.1248/bpb.b18-00638.

PMID:: 31257285

Free Article

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Select item 3120904710.

Pak2 kinase promotes cellular senescence and organismal aging.

Lee JS, Mo Y, Gan H, Burgess RJ, Baker DJ, van Deursen JM, Zhang Z.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13311-13319. doi: 10.1073/pnas.1903847116. Epub 2019 Jun 17.

PMID:: 31209047

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Select item 3120138211.

BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules.

Huang Y, Lin L, Liu X, Ye S, Yao PY, Wang W, Yang F, Gao X, Li J, Zhang Y, Zhang J, Yang Z, Liu X, Yang Z, Zang J, Teng M, Wang Z, Ruan K, Ding X, Li L, Cleveland DW, Zhang R, Yao X.

Cell Res. 2019 Jul;29(7):562-578. doi: 10.1038/s41422-019-0178-z. Epub 2019 Jun 14.

Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, powered congression of those chromosomes, their segregation in anaphase, and assembly of a spindle midzone at mitotic exit. The centromere-associated kinesin motor CENP-E, whose binding partner is BubR1, has been implicated in congression of misaligned chromosomes and the transition from lateral kinetochore-microtubule association to end-on capture. Although previously proposed to be a pseudokinase, here we report the structure of the kinase domain of Drosophila melanogaster BubR1, revealing its folding into a conformation predicted to be catalytically active. BubR1 is shown to be a bona fide kinase whose phosphorylation of CENP-E switches it from a laterally attached microtubule motor to a plus-end microtubule tip tracker. Computational modeling is used to identify bubristatin as a selective BubR1 kinase antagonist that targets the αN1 helix of N-terminal extension and αC helix of the BubR1 kinase domain. Inhibition of CENP-E phosphorylation is shown to prevent proper microtubule capture at kinetochores and, surprisingly, proper assembly of the central spindle at mitotic exit. Thus, BubR1-mediated CENP-E phosphorylation produces a temporal switch that enables transition from lateral to end-on microtubule capture and organization of microtubules into stable midzone arrays.

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( Ditchfield, C. et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. 161, 267–280 (2003).

Huom: Kelch proteiinien osuus Aurora B säätelyssä)

Select item 3118440012.

Rhabdomyosarcoma with premature chromatid separation-mosaic variegated aneuploidy syndrome: Reduced-intensity chemotherapy.

Nishitani-Isa M, Hiraumi Y, Nishida Y, Usami I, Maihara T.

Pediatr Int. 2019 Jun;61(6):613-616. doi: 10.1111/ped.13849. Epub 2019 Jun 11. No abstract available.