GTP, GDP, GMP, Guanosiini, Mitokondriaalinen entsyymi dG kinaasi (DGUOK) tuottaa dGMP

 dG  kinaasi: 

 DGUOK 2p13.1

• GeneCards Symbol: DGUOK ²
• Deoxyguanosine Kinase ^{2 3 5}
• DGK ^{2 3 4 5}
• Deoxyguanosine Kinase, Mitochondrial ^{3 4}
• Deoxyadenosine Kinase, Mitochondrial ^{3 4}
• EC 2.7.1.113 ⁴

• EC 2.7.1.76 ⁴
• MTDPS3 ³
• NCPH1 ³
• PEOB4 ³
• NCPH ³
•  

  Function:

  • Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:8692979, 8706825, 11687801, 17073823, 23043144).
    In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2.
    Phosphorylates certain nucleoside analogs (By similarity).
    Widely used as target of antiviral and chemotherapeutic agents. DGUOK_HUMAN,Q16854

  CatalyticActivity:

  • Reaction=2'-deoxyguanosine + ATP = ADP + dGMP + H(+); Xref=RHEA:19201, CHEBI:15378, CHEBI:17172, CHEBI:30616, CHEBI:57673, CHEBI:456216; EC=2.7.1.113; Evidence={ECO:0000269 PubMed:11687801, 17073823, 23043144, 8692979, 8706825}. DGUOK_HUMAN,Q16854
  • Reaction=2'-deoxyadenosine + ATP = ADP + dAMP + H(+); Xref=RHEA:23452, CHEBI:15378, CHEBI:17256, CHEBI:30616, CHEBI:58245, CHEBI:456216; EC=2.7.1.76; Evidence={ECO:0000269 PubMed:17073823, 8692979, 8706825}. DGUOK_HUMAN,Q16854