Mediators Inflamm. 2012;2012:148039. doi: 10.1155/2012/148039. Epub 2012 Aug 29.
Proteomic analyses of the vitreous humour.
Abstract
The human vitreous
humour (VH) is a transparent, highly hydrated gel, which occupies the
posterior segment of the eye between the lens and the retina.
Physiological and pathological conditions of the retina are reflected in
the protein composition
of the VH, which can be sampled as part of routine surgical procedures.
Historically, many studies have investigated levels of individual
proteins in VH from healthy and diseased eyes. In the last decade,
proteomics analyses have been performed to characterise the proteome of
the human VH and explore networks of functionally related proteins,
providing insight into the aetiology of diabetic retinopathy and
proliferative vitreoretinopathy. Recent proteomic studies on the VH from
animal models of autoimmune uveitis have identified new signalling
pathways associated to autoimmune triggers and intravitreal
inflammation. This paper aims to guide biological scientists through the
different proteomic techniques that have been used to analyse the VH
and present future perspectives for the study of intravitreal
inflammation using proteomic analyses.
Free PMC Article
Lasiaisneste, vitreous humor, Corpus vitreum, glaskropp
Lasiaisneste, vitreous humor, Corpus vitreum, glaskropp
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