Beilstein J Org Chem. 2013 Nov 12;9:2434-45. doi: 10.3762/bjoc.9.281.
Biosynthesis of rare hexoses using microorganisms and related enzymes.
- 1
- The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
- 2
- School of Food Science and Technology, Jiangnan University, Wuxi, 214122, China.
- 3
- Division of Mathematics and Science, University of South Carolina Salkehatchie, Walterboro, South Carolina, 29488, USA.Abstract
Rare
sugars, referred to as monosaccharides and their derivatives that
rarely exist in nature, can be applied in many areas ranging from
foodstuffs to pharmaceutical and nutrition industry, or as starting
materials for various natural products and drug candidates.
Unfortunately, an important factor restricting the utilization of rare
sugars is their limited availability, resulting from limited synthetic
methods. Nowadays, microbial and enzymatic transformations have become a
very powerful tool in this field. This article reviews the biosynthesis
and enzymatic production of rare ketohexoses, aldohexoses and sugar
alcohols (hexitols), including D-tagatose, D-psicose, D-sorbose,
L-tagatose, L-fructose, 1-deoxy-L-fructose, D-allose, L-glucose,
L-talose, D-gulose, L-galactose, L-fucose, allitol, D-talitol,
and L-sorbitol. New systems and robust catalysts resulting from
advancements in genomics and bioengineering are also discussed. KEYWORDS:
biosynthesis; enzyme; hexose; microorganism; rare sugars
- Seleno-D- talitolista hyviä sanoja:
- Mucoraceae sienet hyödyntävät D- talitolia.
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