Maksan toiminnan kvantitatiivisia testejä . Merkitys , esim. PBC diagnostiikka , Tässä kiinnitän huomion kahteen sokeriaineenvaihdunnan molekyyliin, galaktoosiin ja sorbitoliin, joka on sokerialkoholi. Molemmista pitäisi lopputuotteena saada tarvitaessa tärkeinä biologista polttoainetta glukoosia, muta eri taudeissa näissä teissä on esteitä. Maksa on kehossa suurin metabolisen kyvyn opmaava koneisto. .
QTLF included aminopyrine breath test, galactose elimination capacity, sorbitol and indocyanine green clearance.
- 2002 Apr;22(2):159-65.
PMID:
12028411
DOI:
10.1034/j.1600-0676.2002.01641.x
Abstract
Abstract: Aim: Primary biliary cirrhosis (PBC) is a slowly progressive liver disease which can lead to cirrhosis. We investigated if quantitative tests of liver function (QTLF) and serum levels of a surrogate marker of hepatic fibrogenesis (PIIINP) provide information in addition to established prognostic scores.
Methods: In 34 PBC patients PIIINP, PBC-relevant parameters, histological staging and QTLF at entry and at 2 years were determined and compared with the Christensen (CPS I, CPS II) and Mayo prognosis score. QTLF included aminopyrine breath test, galactose elimination capacity, sorbitol and indocyanine green clearance.
Results: Bilirubin, serum IgM and PIIINP were elevated at both time points, whereas albumin and prothrombin time remained normal. Clinical findings (ascites, cirrhosis, central cholestasis) and histological staging worsened after 2 years, as did the CPS II. However, QTLF, PIIINP, CPS I and the Mayo score revealed no significant changes.
Conclusions: Only CPS II changed after 2 years, whereas CPS I and the Mayo score remained unaltered. QTLF and PIIINP did not provide any further information on progression of PBC, suggesting that QTLF cannot predict prognosis of PBC patients in a two-year interval and that CPS II is superior to CPS I and the Mayo score in short-term studies for PBC.
Inga kommentarer:
Skicka en kommentar