Viime päivien aihepiiri entsymaattinen glykosylaatio ja nonentsymaattinen randomglykaatio, eroja. Ensinnäkin Tn syntetaasigeenistä.

 Tn  syntetaasi

https://www.genecards.org/cgi-bin/carddisp.pl?gene=ST6GALNAC1&keywords=Tn

• GeneCards Symbol: ST6GALNAC1 2 
• ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 2 3 5
• ST6GalNAcI 2 3 4 5
• SIAT7A 3 4 5
• Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) A 2 3
• ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 2 3
• Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 3 4
• ST6 GalNAc Alpha-2,6-Sialyltransferase 1 2 3
• GalNAc Alpha-2,6-Sialyltransf

• NCBI Gene Summary for ST6GALNAC1 Gene

   

  • Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]

  GeneCards Summary for ST6GALNAC1 Gene

  ST6GALNAC1 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1) is a Protein Coding gene. Diseases associated with ST6GALNAC1 include Colitis and Ulcerative Colitis. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GALNAC2.

  UniProtKB/Swiss-Prot Summary for ST6GALNAC1 Gene

  Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis (PubMed:35303419). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins (PubMed:10536037, 15466199, 16319059, 31719620, 35303419). Catalyzes the formation of the sialyl-Tn (S-Tn) antigen, an antigen found in intestinal goblet cells, as well as ulcerative colitis (UC) and various cancers (PubMed:15466199, 16319059, 31719620, 35303419). Protein sialylation in globlet cells is essential for mucus integrity and is required to protect the intestinal mucus against excessive bacterial proteolytic degradation (PubMed:35303419). ( SIA7A_HUMAN,Q9NSC7 )