Lapsuusdiabeteksen prevalenssi Israelissa

 Lapsuusdiabeteksen  prevalenssia on vertailtu Israelin juutalaissyntyisten ja arabisyntyisten kesken. 
jolloin on saatu kaksi eri geeniaineistoa  vertailuun- Juutalaisissa on luonollsesti suuri osa niitä jotka ovat palanneet eri puolilta maailmaa "suuresta  2000 vuoden geenimyllystä" ja arabeissa suuri osa  niitä, jotka ovat  kaiketi asuneet Lähi-Idän, Välimeren  alueella   ehkä viimeiset 2000 vuotta joten vertailu on merkitsevä koko ihmiskuntagenomin suhteen. 

Pediatr Diabetes. 2014 Sep;15(6):422-7. doi: 10.1111/pedi.12101. Epub 2013 Nov 27.

Trends in the incidence of type 1 diabetes among Jews and Arabs in Israel.

Blumenfeld O¹, Dichtiar R, Shohat T; Israel IDDM Registry Study Group (IIRSG).

Collaborators (63)

Abstract

OBJECTIVE:

To assess the trends in the incidence of type 1 diabetes between 1997 and 2010 among 0-17-yr-old Israeli Jews and Arabs compared with global trends.

METHODS:

Data on children with newly diagnosed type 1 diabetes reported by pediatric endocrinologists from 19 medical centers to the Israel Center for Disease Control, as part of the National Diabetes Register.

RESULTS:

During 1997-2010, 2857 Jews and 757 Arabs were diagnosed with type 1 diabetes.

 The average age-adjusted incidence among Jews was higher than Arabs
 [12.2 per 100 000, 95% confidence interval (CI) 10.5-14.2
and 8.9 per 100 000, 95% CI 7.5-10.7, p = 0.0001, respectively],
 however, the annual percent change was higher for Arabs compared with Jews (4.0 vs. 3.6%, p = 0.005, respectively).

 The mean age at diagnosis was similar for Jews and Arabs (9.6 ± 4.4 vs. 9.9 ± 4.4 yr, p = 0.08), and it remained stable during 1997-2010 in both ethnic groups (p = 0.6).

In both Jews and Arabs the highest annual percent change was observed in younger children. It was 4.9% for children aged 5-9 yr and 10.7% for children aged 0-4 yr, respectively.
 There were no differences in the frequency of diabetic ketoacidosis (DKA) between Jews (39.9%) and Arabs (41.3%), (p = 0.5).

CONCLUSION:

Type 1 diabetes incidence of Jews and Arabs in Israel is increasing. The incidence is higher in Jews than in Arabs; however, the annual percent change is higher in Arabs than in Jews. In both Ethnic groups the incidence of type 1 diabetes is increasing especially among young children.

© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.