E3 ubikitiiniligaasi sokeriaineenaihdunnasta

 F(1,6) bifosfataasin entsymin hajoittaa  u´E3 ubikitiiniligaasi, joka hajoaa myös itse proteosomilla.

Muut E3 ubikitiiniligaasit

•  HiilihydraattiaineenvaihduntaHiivassa:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488282/

Mol Biol Cell. 2008 Aug; 19(8): 3323–3333.

doi:  [10.1091/mbc.E08-03-0328]

PMCID: PMC2488282

PMID: 18508925

The Yeast GID Complex, a Novel Ubiquitin Ligase (E3) Involved in the Regulation of Carbohydrate Metabolism

Olivier Santt,^*† Thorsten Pfirrmann,^*†‡ Bernhard Braun,^* Jeannette Juretschke,^* Philipp Kimmig,^* Hartmut Scheel,^§ Kay Hofmann,^§ Michael Thumm,^*‖ and Dieter H. Wolf^*

Thomas Sommer, Monitoring Editor

Author information Article notes Copyright and License information Disclaimer

The Gid complex, a novel ubiquitin ligase (E3) required for the degradation of the key gluconeogenic enzyme fructose-1,6-bisphosphatase. The Gid complex binds to FBPase, when S. cerevisiae cells are growing on an ethanol-containing medium. On shift of cells to glucose, Gid4/Vid24 occurs and activates the complex, which then polyubiquitinates FBPase before its degradation by the proteasome. Gid4/Vid24 is itself degraded by the proteasome.

PEPCK, another gluconeogenic enzyme, is also subject to catabolite degradation (Holzer, 1976 ; Muller et al., 1981 ). As Figure 7 shows, it is stabilized in GID2/RMD5 and GID4/VID24 deleted cells. Thus, Gid complex-dependent degradation is not restricted to FBPase but plays a more general role within the regulation of carbohydrate metabolism.
Gid protein homologues were also found to form a complex in mammals (Kobayashi et al., 2007 ). Although no function for this CTLH complex has been described, one subunit has been implicated in proteasomal degradation of α-catenin (Suzuki et al., 2008 ). This suggests that the CTLH complex, like the Gid complex, might also bear E3 activity.
In conclusion (Figure 8), our study shows that the Gid complex is a new ubiquitin ligase with novel types of subunits involved in catabolite degradation of gluconeogenic enzymes in yeast. We also identify Vid24/Gid4 as an important regulator of its ubiquitin ligase activity.

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Löytyy kaksi geeniä
RMD5A, GID2A, CTLH , Kr. 2 required for meiotic division
RMD5B, GID2B, kr.5
required ofr meiotic nuclear division
Katson näistä  enemmän tietoa  onko niillä  yhteyttä sokeriaineenvaihduntaan kuten hiivassa, josa se hajoitaa fruktoosi1,6,-bifosfaataasia.