Inositoliaineenvaihdunta kärsii "tyhjien kalorien" dieetistä

Inositoli on hyödyllinen polyoli. Sitä  saadaan inositolifosfaatteina kuitupitoisen ravinnon joukossa  täystjyvissä, siemenissä, pähkinöissä, müslissä, puuroissa, kaakaossa, Inositoliheksafosfaatti on  antioksidanttinen kehon aineenvaihdunnassa.  Inositolipolyoli  omaa kuusi OH- ryhmää ja jokaiseen  voi asettua fosfaatti (esim  inositoliheksafosfaatti IP6) Ravinsossa  olevaa IP6-muotoa  sanotaan  "fytiiniksi". (Kehossa on inositoliaineenvaihdunnassa useita kymmeniå eri molekyylejä   syklinä. Tämä sykli on tärkeä esim.  harmaan aivokuoren soluissa). 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666868/

Int J Mol Sci. 2017 Oct; 18(10): 2187.

Published online 2017 Oct 20. doi:  [10.3390/ijms18102187]

PMCID: PMC5666868

PMID: 29053604

Nutritional and Acquired Deficiencies in Inositol Bioavailability. Correlations with Metabolic Disorders

Simona Dinicola,^1,2 Mirko Minini,^1,2 Vittorio Unfer,³ Roberto Verna,¹ Alessandra Cucina,^2,4 and Mariano Bizzarri^1,*

 Abstract

Communities eating a western-like diet, rich in fat, sugar and significantly deprived of fibers, share a relevant increased risk of both metabolic and cancerous diseases. Even more remarkable is that a low-fiber diet lacks some key components—as phytates and inositols—for which a mechanistic link has been clearly established in the pathogenesis of both cancer and metabolic illness. Reduced bioavailability of inositol in living organisms could arise from reduced food supply or from metabolism deregulation. Inositol deregulation has been found in a number of conditions mechanistically and epidemiologically associated to high-glucose diets or altered glucose metabolism. Indeed, high glucose levels hinder inositol availability by increasing its degradation and by inhibiting both myo-Ins biosynthesis and absorption. These underappreciated mechanisms may likely account for acquired, metabolic deficiency in inositol bioavailability.

Keywords: myo-Inositol, phytate (InsP6), diabetes, myo-inositol oxygenase (MIOX), diabetic nephropathy, cancer, inositol hexakisphosphate kinase (IP6K1), phosphatidic acid, Inositol-3-Phosphate Synthase 1 (ISYNA1)