Purinerginen reseptori betasolussa ja eNTPD3

https://www.ncbi.nlm.nih.gov/gene/956

Official Symbol

ENTPD3provided by HGNC

Official Full Name

ectonucleoside triphosphate diphosphohydrolase 3provided by HGNC

Primary source

HGNC:HGNC:3365

See related

Ensembl:ENSG00000168032 MIM:603161; Vega:OTTHUMG00000131390

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

HB6; CD39L3; NTPDase-3

Summary

This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]

 

GeneRIFs: Gene References Into Functions

1. Despite the increased level of NTPDase1 and NTPDase3 mRNA expression in chondrogenically induced MSCs, their activity toward ATP remains quite low.
2. NTPDase3 is the major ectonucleotidase in pancreatic beta-cells in multiple species and modulates insulin secretion by controlling activation of purinergic receptors.
3. Cystic fibrosis epithelia exhibit >50% lower NTPDase1 activity, protein, and mRNA levels than normal epithelia, whereas these parameters are threefold higher for NTPDase3.
4. Generation of a helical model for NTPDase3 suggests the importance of putative hydrogen bond interactions of conserved polar residues which are critical for enzyme expression, activity, and its susceptibility to membrane perturbations.
5. efficiently inhibit the NTPDase3expressed in insulin secreting human pancreatic islet cells in situ
6. NTPDase3 sequence revealed a high degree of structural fold similarity with a bacterial exopolyphosphatase