Väitöstilaisuus (Daniel Nilsson) : insuliiniherkkyyden ja insuliiniresisenssin taustageenejä koeteltiin koe-eläimessä.

*Forkhead genes in adipocytes and podocytes
Nilsson, Daniel
2016-11-18 ( Tämän väitöstilaisuuden kävin kuuntelemassa klo 13 -17 välillä)

Taustaterminologia  Forkhead geenit. Näistä löytyy luettelo  netissäkin: ne kuuluvat transkriptiotekijöihin, joiten joukko on nykyään jo 2-3000, eikä 1500, kuten  edellisessä muistiinpanossani mainitsin blogiin. Näsitä on runsaat  40 Forkhead-geenejä, ryhmän jäseniä. Näistä tutkija valitsi FOXC2 ja FOXF2 lähemmin tutkittavaksi ja niillä on  vastakkaisia metabolisia vaikutuksia.
Työ oli tehty hiirillä, joiden vastaavalla FOXC2.geenillä on ihmisgeenin kanssa 85% homologia.
 https://en.wikipedia.org/wiki/FOX_proteins
Otan tässä kuitenkin esiin tiedot näistä ihmisgeeneistä .

•  Geeni FOX2F. Sijainti kr.625.3.  muut nimet FKHL6, FREAC, FREAC-2. Tätä lötyy keuhksota ja placentasta.   "FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008]"

Lisätietoa tästä geenistä:  https://www.ncbi.nlm.nih.gov/gene/2295

Siteeraan FOXC2 geenin tietoja tähän alle.

• Geeni FOXC2. Sijainti kr.16q24.1

Muut nimet:  LP, KFH1, MFH-1, FKHL14.
Löytyvää tekstiä: "This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]"
https://www.ncbi.nlm.nih.gov/gene/2303 

Related articles in PubMed

1. Correlations of FOXC2 Gene Expression and Polymorphism with Type 2 Diabetes Mellitus. Nian X, et al. Clin Lab, 2016. PMID 27349002
2. Overexpression of transcription factor FOXC2 in cultured human podocytes upregulates injury markers and increases motility. Datta N, et al. Exp Cell Res, 2016 Jan 1. PMID 26524507
3. Effects of forkhead box C2 on carcinogenesis and lymphatic metastasis in endometrial carcinoma. Fan YY, et al. Genet Mol Res, 2015 May 25. PMID 26125751
4. FOXC2 promotes chemoresistance in nasopharyngeal carcinomas via induction of epithelial mesenchymal transition. Zhou Z, et al. Cancer Lett, 2015 Jul 28. PMID 25896630
5. High expression of forkhead box protein C2 is related to poor prognosis in human gliomas. Wang YW, et al. Asian Pac J Cancer Prev, 2014. PMID 25605149
6.  
   GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
7. Evaluation of FoxC2 expression, alone or in combination with E-cadherin expression, may help to stratify non-small cell lung cancer patients for risk of disease progression, pointing to this EMT regulator as a potential prognostic marker
8. Data indicate the role for altered forkhead box C2 (FoxC2)-Delta-like ligand 4 (Dll4)signaling in structural alterations of saphenous veins in patients with varicose veins.
9. FOXC2 gene is associated with the glycolipid metabolic abnormality in T2DM patients.
10. Adenovirus-mediated FoxC2 expression enhances BMP7-facilitated anabolism in nucleus pulposus cells of the intervertebral discs.
11. The data indicate that the expression of FOXC2 in podocytes needs to be tightly regulated, and that its overexpression induces a chain of cellular events leading to podocyte dysfunction.
12. Peri-tumoral lymphatics were associated with increased lymphatic metastasis. FOXC2 may be associated with the genesis of endometrial carcinoma and lymphangiogensis in endometrial adenocarcinoma in intra- and peri-tumoral lymphatics.
13. our findings contribute to the putative targets in which the FLT4 gene mutation was found to have a significant role in lymphatic filariasis, while FOXC2 and FLT4 SNP interactions need to be further elucidated at a functional level.
14. High FOXC2 expression is associated with tumor proliferation and invasion potential in oral tongue squamous cell carcinoma.
15. In cultured lymphatic endothelial cells, FOXC2 inactivation conferred abnormal shear stress sensing, promoting junction disassembly and entry into the cell cycle. This was mediated by TAZ and led to cell death.

we propose that Foxc2 is functionally maintained in the cytoplasm of normal epithelial cells by CK2alpha/alpha'-mediated phosphorylation at serine 124, which is dependent on proper targeting of the holoenzyme via the CK2b regulatory subunit.