Beetasolun kalsium-oskillaatiosta ja muusta

 Tässä taas pääseen mieliaiheeseeni, josta enemmän on Fytiiniblogissani.
Siirryn fosfaatin tasapainotuksen alueelle. Toivon tasapainotettavan ravinnon  fosfaattia kasvisperäisen fosfaatin eduksi enemmän, jotta  tämä kalsiumoskillaatio solujen sisällä  pääsee oikenemaan.
 http://diabetes.diabetesjournals.org/content/54/11/3073

Ettei mahdollinen lukija pitkästyisi jahnaavaan tyyliini, en tässä tämän enempää tästä.

Paitsi :http://diabetes.diabetesjournals.org/content/65/2/314

Conclusions

The protection and regeneration of insulin-producing pancreatic islet β-cells of the endocrine pancreas is a major focus of diabetes research (3,4). 

 Compared with other adult tissues, the endocrine pancreas exhibits considerable plasticity in that many stimuli, including age, nutrition, pregnancy, insulin sensitivity, excessive caloric intake, and various paradigms of damage, can affect β-cell proliferation and alter β-cell mass, at least in experimental rodent models.

 Understanding the signal transduction pathways behind these phenomena will provide potentially new therapeutic avenues. 

Clues are provided by reports of experimental interventions that manipulate β-cell mass using treatments with known downstream signaling pathways.

 These include

 hyperglycemia,

 incretins, 

Nodal (a TGF-β family member), 

vascular endothelial growth factor,

Wnt pathway activators, and

 γ-aminobutyric acid, for example (4). 

 Additional clues are provided by reports pointing out the importance of transcription factors in the specification of the β-cell fate,

 including Pdx1,

 MafA, and 

Ngn3 (130).

It is important to elucidate in detail how these signaling pathways regulate their downstream transcription factors to provide a deeper understanding of pancreatic development and function and to give more precise direction to drug discovery programs.

 Recent evidence suggests that the view that a signaling pathway is on/off or high/low may be too simplistic because it does not account for the operation of alternative (noncanonical) branches of these pathways that may be highly active while canonical branches may be suppressed.

 In an example of cross-disciplinary approach, the NSC field may provide a template to evaluate the involvement of such noncanonical signaling pathway branches in pancreatic development and function, providing new ideas that may help understand and manipulate better the plasticity of this organ.