EfriiniB puolestaan on viereisessa solussa oleva trasnmembraaninenproteiini, Efriini A on linkkiytynyt GPI-ankkurilla. ( Näitä useita näissä soluperheissä)
http://www.nature.com/nrm/journal/v17/n4/abs/nrm.2015.16.html
https://www.ncbi.nlm.nih.gov/pubmed/17448994
Cell. 2007 Apr 20;129(2):359-70.
EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets.
Konstantinova I1, Nikolova G, Ohara-Imaizumi M, Meda P, Kucera T, Zarbalis K, Wurst W, Nagamatsu S, Lammert E.
Abstract
In vertebrates, beta cells are aggregated in the form of pancreatic islets. Within these islets, communication between beta cells
In the search for the underlying molecular mechanism, we have discovered that beta cells communicate via ephrin-As and EphAs.
We provide evidence that ephrin-A5 is required for glucose-stimulated insulin secretion (GSIS)
. We further show that EphA-ephrin-A-mediated beta cell communication is bidirectional: EphA forward signaling inhibits insulin secretion, whereas ephrin-A reverse signaling stimulates insulin secretion.
EphA forward signaling is downregulated in response to glucose, which indicates that, under basal conditions, beta cells use EphA forward signaling to suppress insulin secretion and that, under stimulatory conditions, they shift to ephrin-A reverse signaling to enhance insulin secretion.
Thus, we explain how beta cell communication in pancreatic islets conversely affects basal and glucose-stimulated insulin secretion to improve glucose homeostasis.
- inhibits basal insulin secretion and
- enhances glucose-stimulated insulin secretion,
In the search for the underlying molecular mechanism, we have discovered that beta cells communicate via ephrin-As and EphAs.
We provide evidence that ephrin-A5 is required for glucose-stimulated insulin secretion (GSIS)
. We further show that EphA-ephrin-A-mediated beta cell communication is bidirectional: EphA forward signaling inhibits insulin secretion, whereas ephrin-A reverse signaling stimulates insulin secretion.
EphA forward signaling is downregulated in response to glucose, which indicates that, under basal conditions, beta cells use EphA forward signaling to suppress insulin secretion and that, under stimulatory conditions, they shift to ephrin-A reverse signaling to enhance insulin secretion.
Thus, we explain how beta cell communication in pancreatic islets conversely affects basal and glucose-stimulated insulin secretion to improve glucose homeostasis.
Comment in
- PMID:
- 17448994
- DOI:
- 10.1016/j.cell.2007.02.044
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